Macon: An Architectural & Historical Guide (Middle Georgia Historical Society, Macon, 1996) notes that the first owner of this house was Virgil Powers, who served as superintendent of the Southwestern Railroad, a surveyor for the railroad to Savannah in 1834, a city alderman and a charter member of the Bibb County Board of Education. It was originally a simple frame house with Italianate and Neoclassical elements added later. Other owners listed are LeConte and Blackshear. The only LeConte I can locate in Macon in the antebellum era is Joseph LeConte, who maintained a medical practice in Macon from 1847 to 1850.
Macon Historic District, National Register of Historic Places
also LeConte Blackshear Powers House with an 1841 date?